SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
7
INPP5E's impact on medulloblastoma
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Significant relevance for future therapy
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
8
Boosted brain function
Helps keep the nervous system, digestive system, and skin in good condition. It reduced my cholesterol and provided a boost to my brain function.
Read More
9.5
Lighter brain feeling
This product is flash-free and safe, ideal for physical and mental disorders resulting from dopamine overactivity. My brain felt noticeably lighter after use.
Read More
8.8
Increased brain energy
The quality of this product is excellent. The package size is manageable for storage. The ingredients are beneficial for me, enhancing my brain energy and reducing stress. I appear younger, and my immunity has strengthened. It also tastes delightful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
7
INPP5E's impact on medulloblastoma
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Significant relevance for future therapy
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Boosted brain function
Helps keep the nervous system, digestive system, and skin in good condition. It reduced my cholesterol and provided a boost to my brain function.
9.5
Lighter brain feeling
This product is flash-free and safe, ideal for physical and mental disorders resulting from dopamine overactivity. My brain felt noticeably lighter after use.
8.8
Increased brain energy
The quality of this product is excellent. The package size is manageable for storage. The ingredients are beneficial for me, enhancing my brain energy and reducing stress. I appear younger, and my immunity has strengthened. It also tastes delightful.
8.8
Reduced brain fog
I experienced increased energy and relief from brain fog, along with lowered blood lipids. The niacin content is beneficial, with no flushing.
7.5
Enhanced brain clarity
Niacin (vitamin B3) is vital, and Inositol hexaniacinate is a "non-flushing" form that helps lower harmful cholesterol. It helps maintain a healthy metabolism, promotes blood circulation, and dilates blood vessels. After taking it, I noticed a rosier complexion and a reduction in brain fog.
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